|Application ||WB, E|
|Calculated MW||37909 Da|
|Antigen Region||131-159 aa|
|Other Names||GRB2-related adapter protein 2, Adapter protein GRID, GRB-2-like protein, GRB2L, GRBLG, GRBX, Grf40 adapter protein, Grf-40, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, P38, Protein GADS, SH3-SH2-SH3 adapter Mona, GRAP2, GADS, GRB2L, GRID|
|Target/Specificity||This GRAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-159 amino acids from the Central region of human GRAP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRAP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GADS, GRB2L, GRID|
|Function||Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.|
|Cellular Location||Nucleus. Cytoplasm. Endosome|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Preisinger, C., et al. Cell. Signal. 22(5):848-856(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
Ludwig, L., et al. Cancer Lett. 275(2):194-197(2009)
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