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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   SP100 Antibody (N-term)   

SP100 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SP100 Antibody (N-term) AP14754a
    SP100 Antibody (N-term) (Cat. #AP14754a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SP100 antibody detected the SP100 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23497
Other Accession NP_001073860.1, NP_003104.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 100417 Da
Antigen Region 199-227 aa
Additional Information
Gene ID 6672
Other Names Nuclear autoantigen Sp-100, Nuclear dot-associated Sp100 protein, Speckled 100 kDa, SP100
Target/Specificity This SP100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-227 amino acids from the N-terminal region of human SP100.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSP100 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SP100
Function Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
Cellular Location Nucleus. Nucleus, PML body. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon- dependent. Accumulates in the cytoplasm upon FAS activation
Tissue Location Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines
Research Areas
Citations (0)

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SP100 may play a role in the control of gene expression.


Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Li, W., et al. Med. Sci. Monit. 16 (6), BR174-BR178 (2010) :
Lang, M., et al. J. Cell. Sci. 123 (PT 3), 392-400 (2010) :

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$ 295.00
$ 99.00
Cat# AP14754a
(40 western blots)
Availability: In Stock
Bulk Size
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