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HTATIP2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HTATIP2 Antibody (N-term) AP14762a
    HTATIP2 Antibody (N-term) (Cat. #AP14762a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HTATIP2 antibody detected the HTATIP2 protein (arrow).
  • IHC-P - HTATIP2 Antibody (N-term) AP14762a
    HTATIP2 Antibody (N-term) (AP14762a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HTATIP2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BUP3
Other Accession Q9Z2G9, NP_001091991.1, NP_001091993.1, NP_001091992.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27049 Da
Antigen Region 45-74 aa
Additional Information
Gene ID 10553
Other Names Oxidoreductase HTATIP2, 111-, 30 kDa HIV-1 TAT-interacting protein, HIV-1 TAT-interactive protein 2, HTATIP2 (HGNC:16637)
Target/Specificity This HTATIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human HTATIP2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHTATIP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTATIP2 (HGNC:16637)
Function Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Cellular Location Cytoplasm. Nucleus envelope
Tissue Location Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas
Research Areas
Citations (0)

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Background

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

References

Chen, X., et al. Dig. Dis. Sci. 55(8):2219-2226(2010)
Fong, S., et al. BMC Cell Biol. 11, 23 (2010) :
Nakahara, J., et al. Expert Opin. Ther. Targets 13(12):1375-1386(2009)
Tong, X., et al. Am. J. Pathol. 174(5):1931-1939(2009)
Nakahara, J., et al. J. Clin. Invest. 119(1):169-181(2009)

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$ 295.00
$ 99.00
Cat# AP14762a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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