|Application ||WB, IHC-P, E|
|Other Accession||Q9Z2G9, NP_001091991.1, NP_001091993.1, NP_001091992.1|
|Calculated MW||27049 Da|
|Antigen Region||45-74 aa|
|Other Names||Oxidoreductase HTATIP2, 111-, 30 kDa HIV-1 TAT-interacting protein, HIV-1 TAT-interactive protein 2, HTATIP2 (HGNC:16637)|
|Target/Specificity||This HTATIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human HTATIP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HTATIP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.|
|Cellular Location||Cytoplasm. Nucleus envelope|
|Tissue Location||Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas|
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Provided below are standard protocols that you may find useful for product applications.
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Chen, X., et al. Dig. Dis. Sci. 55(8):2219-2226(2010)
Fong, S., et al. BMC Cell Biol. 11, 23 (2010) :
Nakahara, J., et al. Expert Opin. Ther. Targets 13(12):1375-1386(2009)
Tong, X., et al. Am. J. Pathol. 174(5):1931-1939(2009)
Nakahara, J., et al. J. Clin. Invest. 119(1):169-181(2009)
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