|Application ||WB, IHC-P, E|
|Other Accession||Q9JJM9, Q9Z2Q6, NP_002679.2|
|Calculated MW||42777 Da|
|Antigen Region||1-30 aa|
|Other Names||Septin-5, Cell division control-related protein 1, CDCrel-1, Peanut-like protein 1, SEPT5, PNUTL1|
|Target/Specificity||This SEPT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SEPT5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEPT5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules|
|Tissue Location||Expressed at high levels in the CNS, as well as in heart and platelets (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq].
Jung, A.E., et al. Mol. Ther. 16(6):1048-1055(2008)
Amin, N.D., et al. J. Neurosci. 28(14):3631-3643(2008)
Xin, X., et al. J. Histochem. Cytochem. 55(11):1089-1094(2007)
Blaser, S., et al. J. Pathol. 210(1):103-110(2006)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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