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Mouse Insrr Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9WTL4 |
| Other Accession | Q64716, NP_035962.2 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 144875 Da |
| Antigen Region | 1228-1255 aa |
| Gene ID | 23920 |
|---|---|
| Other Names | Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, Insrr, Irr |
| Target/Specificity | This Mouse Insrr antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1228-1255 amino acids from the C-terminal region of mouse Insrr. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Insrr Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Insrr |
|---|---|
| Synonyms | Irr |
| Function | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in the islets as well as in pancreatic beta-cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
References
Hanke, S., et al. Mol. Cell Proteomics 8(3):519-534(2009)
Hoffman, B.G., et al. Genome Biol. 9 (6), R99 (2008) :
Nef, S., et al. Nature 426(6964):291-295(2003)
Kitamura, T., et al. Mol. Cell. Biol. 21(16):5624-5630(2001)
Tsuji, T., et al. Exp. Anim. 50(4):359-360(2001)
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