|Application ||WB, E|
|Other Accession||Q64716, NP_035962.2|
|Calculated MW||144875 Da|
|Antigen Region||1228-1255 aa|
|Other Names||Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, Insrr, Irr|
|Target/Specificity||This Mouse Insrr antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1228-1255 amino acids from the C-terminal region of mouse Insrr.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Insrr Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in the islets as well as in pancreatic beta-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
Hanke, S., et al. Mol. Cell Proteomics 8(3):519-534(2009)
Hoffman, B.G., et al. Genome Biol. 9 (6), R99 (2008) :
Nef, S., et al. Nature 426(6964):291-295(2003)
Kitamura, T., et al. Mol. Cell. Biol. 21(16):5624-5630(2001)
Tsuji, T., et al. Exp. Anim. 50(4):359-360(2001)
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