|Application ||WB, E|
|Other Accession||NP_001069.1, NP_542413.1|
|Calculated MW||81276 Da|
|Antigen Region||295-322 aa|
|Other Names||Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1, L1CAM|
|Target/Specificity||This CD106 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-322 amino acids from the Central region of human CD106.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD106 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)
Jin, C., et al. Coron. Artery Dis. 21(5):273-277(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)
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