|Application ||WB, E|
|Other Accession||NP_001069.1, NP_542413.1|
|Calculated MW||81276 Da|
|Antigen Region||295-322 aa|
|Other Names||Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1, L1CAM|
|Target/Specificity||This CD106 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-322 amino acids from the Central region of human CD106.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD106 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)
Jin, C., et al. Coron. Artery Dis. 21(5):273-277(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)
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