|Application ||WB, E|
|Calculated MW||10365 Da|
|Antigen Region||64-93 aa|
|Other Names||C-X-C motif chemokine 11, Beta-R1, H174, Interferon gamma-inducible protein 9, IP-9, Interferon-inducible T-cell alpha chemoattractant, I-TAC, Small-inducible cytokine B11, CXCL11, ITAC, SCYB11, SCYB9B|
|Target/Specificity||This CXCL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-93 amino acids from the C-terminal region of human CXCL11.|
|Precautions||CXCL11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ITAC, SCYB11, SCYB9B|
|Function||Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.|
|Tissue Location||High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine Also found in epidermal basal layer keratinocytes in skin disorders|
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Provided below are standard protocols that you may find useful for product applications.
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene.
Rot, A. Front. Biosci. 15, 645-660 (2010) :
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Kouroumalis, A., et al. J. Immunol. 175(8):5403-5411(2005)
Booth, V., et al. Protein Sci. 13(8):2022-2028(2004)
Colvin, R.A., et al. J. Biol. Chem. 279(29):30219-30227(2004)
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