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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HBEGF Antibody (Center)   

HBEGF Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HBEGF Antibody (Center) AP14829c
    HBEGF Antibody (Center) (Cat. #AP14829c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HBEGF antibody detected the HBEGF protein (arrow).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99075
Other Accession NP_001936.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23067 Da
Antigen Region 68-96 aa
Additional Information
Gene ID 1839
Other Names Proheparin-binding EGF-like growth factor, Heparin-binding EGF-like growth factor, HB-EGF, HBEGF, Diphtheria toxin receptor, DT-R, HBEGF, DTR, DTS, HEGFL
Target/Specificity This HBEGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the Central region of human HBEGF.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHBEGF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HBEGF
Synonyms DTR, DTS, HEGFL
Function Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Cellular Location Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor
Research Areas
Citations (0)

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Background

HBEGF may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rahman, F.B., et al. Lab. Invest. 90(7):1033-1048(2010)
Hamaoka, M., et al. J. Biochem. 148(1):55-69(2010)
Smirnova, I.S., et al. Tsitologiia 52(5):357-363(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :

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$ 295.00
$ 99.00
Cat# AP14829c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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