|Application ||WB, E|
|Calculated MW||23067 Da|
|Antigen Region||68-96 aa|
|Other Names||Proheparin-binding EGF-like growth factor, Heparin-binding EGF-like growth factor, HB-EGF, HBEGF, Diphtheria toxin receptor, DT-R, HBEGF, DTR, DTS, HEGFL|
|Target/Specificity||This HBEGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the Central region of human HBEGF.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HBEGF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DTR, DTS, HEGFL|
|Function||Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.|
|Cellular Location||Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor|
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Provided below are standard protocols that you may find useful for product applications.
HBEGF may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rahman, F.B., et al. Lab. Invest. 90(7):1033-1048(2010)
Hamaoka, M., et al. J. Biochem. 148(1):55-69(2010)
Smirnova, I.S., et al. Tsitologiia 52(5):357-363(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
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