|Application ||WB, E|
|Calculated MW||57726 Da|
|Antigen Region||14-41 aa|
|Other Names||Fas-activated serine/threonine kinase, FAST kinase, Fastk|
|Target/Specificity||This Mouse Fastk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-41 amino acids from the N-terminal region of mouse Fastk.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Fastk Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor (By similarity). Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.|
|Cellular Location||Mitochondrion matrix. Note=Colocalizes with mitochondrial RNA granules.|
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Provided below are standard protocols that you may find useful for product applications.
Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis (By similarity).
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