|Application ||WB, E|
|Other Accession||Q62662, NP_034367.2, NP_001153016.1|
|Calculated MW||58844 Da|
|Antigen Region||464-491 aa|
|Other Names||Tyrosine-protein kinase FRK, Beta-cell Src-homology tyrosine kinase, BSK, FYN-related kinase, Intestine tyrosine kinase, Frk, Bsk, Iyk|
|Target/Specificity||This Mouse Frk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-491 amino acids from the C-terminal region of mouse Frk.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Frk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.|
|Tissue Location||Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung|
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Provided below are standard protocols that you may find useful for product applications.
Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
Akerblom, B., et al. Mol. Cell. Endocrinol. 270 (1-2), 73-78 (2007) :
Nishimura, M., et al. DNA Res. 11(5):315-323(2004)
Sharov, A.A., et al. PLoS Biol. 1 (3), E74 (2003) :
Cowen, M.S., et al. Alcohol. Clin. Exp. Res. 27(8):1213-1219(2003)
Serfas, M.S., et al. Oncol. Res. 13 (6-10), 409-419 (2003) :
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