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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Gsk3a Antibody (C-term)   

Mouse Gsk3a Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Gsk3a Antibody (C-term) AP14846B
    Mouse Gsk3a Antibody (C-term) (Cat. #AP14846b) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Gsk3a antibody detected the Gsk3a protein (arrow).
  • IHC-P - Mouse Gsk3a Antibody (C-term) AP14846B
    Mouse Gsk3a Antibody (C-term) (AP14846b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse lymph node(mandibular) followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Gsk3a Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q2NL51
Other Accession NP_001026837.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51661 Da
Antigen Region 348-376 aa
Additional Information
Gene ID 606496
Other Names Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine/threonine-protein kinase GSK3A, Gsk3a
Target/Specificity This Mouse Gsk3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-376 amino acids from the C-terminal region of mouse Gsk3a.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Gsk3a Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Gsk3a
Function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Research Areas
Citations (0)

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Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).


Ahmad, I., et al. Oncogene (2010) In press :
Beurel, E., et al. Neuroscience 169(3):1063-1070(2010)
Zhou, J., et al. J. Clin. Invest. 120(7):2280-2291(2010)
Wang, Z., et al. Cancer Cell 17(6):597-608(2010)
Spokoini, R., et al. Mol. Endocrinol. 24(6):1136-1150(2010)

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$ 295.00
$ 99.00
Cat# AP14846B
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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