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PRKRIR Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43422 |
| Other Accession | NP_004696.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87704 Da |
| Antigen Region | 102-130 aa |
| Gene ID | 5612 |
|---|---|
| Other Names | 52 kDa repressor of the inhibitor of the protein kinase, p52rIPK, 58 kDa interferon-induced protein kinase-interacting protein, p58IPK-interacting protein, Death-associated protein 4, THAP domain-containing protein 0, PRKRIR, DAP4, P52RIPK, THAP0 |
| Target/Specificity | This PRKRIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the N-terminal region of human PRKRIR. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRKRIR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THAP12 (HGNC:9440) |
|---|---|
| Function | Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth.
References
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Lee, J.H., et al. Korean J Gastroenterol 42(6):484-495(2003)
Lin, Y., et al. J. Biol. Chem. 277(50):47991-48001(2002)
Saelens, X., et al. J. Biol. Chem. 276(45):41620-41628(2001)
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