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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FDPS Antibody (N-term)   

FDPS Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FDPS Antibody (N-term) AP14864a
    FDPS Antibody (N-term) (Cat. #AP14864a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the FDPS antibody detected the FDPS protein (arrow).
  • WB - FDPS Antibody (N-term) AP14864a
    Western blot analysis of FDPS (arrow) using rabbit polyclonal FDPS Antibody (N-term) (Cat. #AP14864a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDPS gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14324
Other Accession NP_001129293.1, NP_001129294.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48275 Da
Antigen Region 54-82 aa
Additional Information
Gene ID 2224
Other Names Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Target/Specificity This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human FDPS.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFDPS Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FPS, KIAA1293
Function Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.


Ishimoto, K., et al. Biochem. J. 429(2):347-357(2010)
Choi, H.J., et al. Yonsei Med. J. 51(2):231-238(2010)
Li, J., et al. J. Immunol. 182(12):8118-8124(2009)
Romanelli, M.G., et al. Genomics 93(3):227-234(2009)
Marini, F., et al. Curr Med Res Opin 24(9):2609-2615(2008)

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$ 295.00
$ 99.00
Cat# AP14864a
(40 western blots)
Availability: In Stock
Bulk Size
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