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TADA2L Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75478 |
| Other Accession | Q6AYE3, Q8CHV6, Q3SZP8, NP_597683.2, NP_001479.3 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51506 Da |
| Antigen Region | 202-230 aa |
| Gene ID | 6871 |
|---|---|
| Other Names | Transcriptional adapter 2-alpha, Transcriptional adapter 2-like, ADA2-like protein, TADA2A, TADA2L |
| Target/Specificity | This TADA2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of human TADA2L. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TADA2L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TADA2A |
|---|---|
| Synonyms | TADA2L |
| Function | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q8CHV6} |
| Tissue Location | Expressed in all tissues, but most abundantly in testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.
References
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Yang, M., et al. Cancer Biol. Ther. 7(1):120-128(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Qian, C., et al. Nat. Struct. Mol. Biol. 12(12):1078-1085(2005)
Barlev, N.A., et al. Mol. Cell. Biol. 23(19):6944-6957(2003)
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