|Application ||WB, E|
|Other Accession||Q9JI91, Q3ZC55, NP_001094.1|
|Calculated MW||103854 Da|
|Antigen Region||751-779 aa|
|Other Names||Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein, ACTN2|
|Target/Specificity||This ACTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-779 amino acids from the C-terminal region of human ACTN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACTN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.|
|Cellular Location||Cytoplasm, myofibril, sarcomere, Z line Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle|
|Tissue Location||Expressed in both skeletal and cardiac muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Chiu, C., et al. J. Am. Coll. Cardiol. 55(11):1127-1135(2010)
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