|Application ||WB, E|
|Other Accession||NP_954629.2, NP_055183.2|
|Calculated MW||40045 Da|
|Antigen Region||334-363 aa|
|Other Names||LIM/homeobox protein Lhx6, LIM homeobox protein 6, LIM/homeobox protein Lhx61, LHX6, LHX61|
|Target/Specificity||This LHX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-363 amino acids from the C-terminal region of human LHX6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LHX6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Jung, S., et al. Oncol. Rep. 23(6):1675-1682(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Estecio, M.R., et al. Oncogene 25(36):5018-5026(2006)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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