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MXI1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MXI1 Antibody (Center) AP14974c
    Anti-MXI1 Antibody (Center) at 1:2000 dilution + human lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 26 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - MXI1 Antibody (Center) AP14974c
    MXI1 Antibody (Center) (Cat. #AP14974c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the MXI1 antibody detected the MXI1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50539
Other Accession O09015, P50540, NP_005953.4, NP_569157.2, NP_001008541.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 26062 Da
Antigen Region 53-82 aa
Additional Information
Gene ID 4601
Other Names Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11, MXI1, BHLHC11
Target/Specificity This MXI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the Central region of human MXI1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMXI1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MXI1
Synonyms BHLHC11
Function Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
Cellular Location Nucleus.
Tissue Location High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle
Citations (0)

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Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.


Lofstedt, T., et al. Exp. Cell Res. 315(11):1924-1936(2009)
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Tsao, C.C., et al. Cancer Biol. Ther. 7(10):1619-1627(2008)
Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)
Dugast-Darzacq, C., et al. FEBS J. 274(17):4643-4653(2007)

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$ 295.00
$ 99.00
Cat# AP14974c
(40 western blots)
Availability: In Stock
Bulk Size
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