|Application ||WB, IHC-P, E|
|Other Accession||P36381, P55917|
|Calculated MW||48229 Da|
|Antigen Region||402-433 aa|
|Other Names||Gap junction alpha-8 protein, Connexin-50, Cx50, Lens fiber protein MP70, GJA8|
|Target/Specificity||This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-433 amino acids from the C-terminal region of human Connexin 50.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Connexin 50 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
|Tissue Location||Eye lens.|
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Provided below are standard protocols that you may find useful for product applications.
GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.
Shiels, A., et al., Am. J. Hum. Genet. 62(3):526-532 (1998). Church, R.L., et al., Curr. Eye Res. 14(10):979-981 (1995). Church, R.L., et al., Curr. Eye Res. 14(3):215-221 (1995).
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