- CITATIONS: 2
|Application ||WB, IHC-P, E|
|Other Accession||P84076, Q06AT1, P84075, Q4PL64|
|Predicted||Rat, Pig, Bovine|
|Calculated MW||22427 Da|
|Antigen Region||2-32 aa|
|Other Names||Neuron-specific calcium-binding protein hippocalcin, Calcium-binding protein BDR-2, HPCA, BDR2|
|Target/Specificity||This Hippocalcin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Hippocalcin.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Hippocalcin Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.|
|Tissue Location||Brain specific..|
Provided below are standard protocols that you may find useful for product applications.
Hippocalcin is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species.
Takamatsu, K., et al., Biochem. Biophys. Res. Commun. 200(1):606-611 (1994).
Hidaka, H., et al., Neurosci. Res. 16(2):73-77 (1993).
Kobayashi, M., et al., Biochem. Biophys. Res. Commun. 189(1):511-517 (1992).
Masaki, T., et al., Gene 225 (1-2), 117-124 (1998).
Ivings, L., et al., Biochem. J. 363 (Pt 3), 599-608 (2002).
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