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Hippocalcin Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P84074 |
| Other Accession | P84076, Q06AT1, P84075, Q4PL64 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22427 Da |
| Antigen Region | 2-32 aa |
| Gene ID | 3208 |
|---|---|
| Other Names | Neuron-specific calcium-binding protein hippocalcin, Calcium-binding protein BDR-2, HPCA, BDR2 |
| Target/Specificity | This Hippocalcin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Hippocalcin. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Hippocalcin Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HPCA (HGNC:5144) |
|---|---|
| Synonyms | BDR2 |
| Function | Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555}. Membrane {ECO:0000250|UniProtKB:P84076}; Peripheral membrane protein {ECO:0000250|UniProtKB:P84076} Note=Association with membranes is calcium-dependent (By similarity) Enriched in the perinuclear region, probably at the trans Golgi network in response to calcium (PubMed:28398555) {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555} |
| Tissue Location | Brain specific.. |
Provided below are standard protocols that you may find useful for product applications.
Background
Hippocalcin is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species.
References
Takamatsu, K., et al., Biochem. Biophys. Res. Commun. 200(1):606-611 (1994).
Hidaka, H., et al., Neurosci. Res. 16(2):73-77 (1993).
Kobayashi, M., et al., Biochem. Biophys. Res. Commun. 189(1):511-517 (1992).
Masaki, T., et al., Gene 225 (1-2), 117-124 (1998).
Ivings, L., et al., Biochem. J. 363 (Pt 3), 599-608 (2002).
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