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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KChIP3 Antibody (N-term M1)   

KChIP3 Antibody (N-term M1)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KChIP3 Antibody (N-term M1) AP1572a
    Western blot analysis of KChIP3 Antibody (N-term M1) (Cat.# AP1572a) in mouse heart tissue lysates (35ug/lane). KChIP3(arrow) was detected using the purified Pab.
  • IHC-P - KChIP3 Antibody (N-term M1) AP1572a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • IHC-P - KChIP3 Antibody (N-term M1) AP1572a
    Formalin-fixed and paraffin-embedded human brain tissue reacted with KChIP3 Antibody (N-term M1) (Cat.#AP1572a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • IF - KChIP3 Antibody (N-term M1) AP1572a
    Confocal immunofluorescent analysis of KChIP3 Antibody (N-term M1) (Cat#AP1572a) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2W7
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 29231 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 30818
Other Names Calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, DREAM, Kv channel-interacting protein 3, KChIP3, KCNIP3, CSEN, DREAM, KCHIP3
Target/Specificity This KChIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KChIP3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKChIP3 Antibody (N-term M1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Cellular Location Cytoplasm. Cell membrane; Lipid-anchor Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000250, ECO:0000269|PubMed:15485870}
Tissue Location Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease
Research Areas
Citations (0)

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KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.


Choi, E.K., et al., Mol. Cell. Neurosci. 23(3):495-506 (2003).
Hong, Y.M., et al., Neurosci. Lett. 340(1):33-36 (2003).
Schrader, L.A., et al., J. Neurosci. 22(23):10123-10133 (2002).
Lilliehook, C., et al., Mol. Cell. Neurosci. 19(4):552-559 (2002).
Cheng, H.Y., et al., Cell 108(1):31-43 (2002).

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$ 295.00
$ 99.00
Cat# AP1572a
(40 western blots)
Availability: In Stock
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