|Application ||IF, WB, E|
|Other Accession||NP_001319.1, NP_001012632.1|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||47535 Da|
|Antigen Region||413-440 aa|
|Other Names||C-terminal-binding protein 1, CtBP1, 111-, CTBP1, CTBP|
|Target/Specificity||This CTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 413-440 amino acids from the C-terminal region of human CTBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in germinal center B-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
Roukens, M.G., et al. Nat. Cell Biol. 12(10):933-942(2010)
Choi, H.J., et al. Biochem. Biophys. Res. Commun. 400(3):396-402(2010)
Merrill, J.C., et al. J. Mol. Biol. 398(5):657-671(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
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