|Application ||WB, E|
|Calculated MW||9118 Da|
|Antigen Region||10-38 aa|
|Other Names||Cytochrome c oxidase subunit 7A1, mitochondrial, Cytochrome c oxidase subunit VIIa-heart, Cytochrome c oxidase subunit VIIa-H, Cytochrome c oxidase subunit VIIa-muscle, Cytochrome c oxidase subunit VIIa-M, COX7A1, COX7AH|
|Target/Specificity||This COX7A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-38 amino acids from the Central region of human COX7A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COX7A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.|
|Cellular Location||Mitochondrion inner membrane.|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Lazarou, M., et al. FEBS J. 276(22):6701-6713(2009)
Ronn, T., et al. Diabetologia 51(7):1159-1168(2008)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
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