|Application ||WB, E|
|Other Accession||NP_057402.1, NP_777362.1, NP_733783.1|
|Calculated MW||51754 Da|
|Antigen Region||81-109 aa|
|Other Names||P2X purinoceptor 2, P2X2, ATP receptor, Purinergic receptor, P2RX2, P2X2|
|Target/Specificity||This P2RX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human P2RX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2RX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Localizes to the apical membranes of hair cells in the organ of Corti|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)
Decker, D.A., et al. Neurogastroenterol. Motil. 22(8):901-908(2010)
Coddou, C., et al. J. Neurosci. 29(39):12284-12291(2009)
Pannek, J., et al. Spinal Cord 47(7):561-564(2009)
Chaumont, S., et al. Sci Signal 1 (41), RA8 (2008) :
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