|Application ||WB, E|
|Calculated MW||84100 Da|
|Antigen Region||353-381 aa|
|Other Names||Mitofusin-1, 365-, Fzo homolog, Transmembrane GTPase MFN1, MFN1|
|Target/Specificity||This MFN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-381 amino acids from the Central region of human MFN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MFN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.|
|Cellular Location||Mitochondrion outer membrane; Multi- pass membrane protein|
|Tissue Location||Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
Perumalsamy, L.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6882-6887(2010)
Park, Y.Y., et al. J. Cell. Sci. 123 (PT 4), 619-626 (2010) :
Onoguchi, K., et al. PLoS Pathog. 6 (7), E1001012 (2010) :
Waxman, A.B., et al. Am. J. Respir. Cell Mol. Biol. 41(4):385-396(2009)
Wolf, C., et al. BMC Med. Genet. 10, 91 (2009) :
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