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C4BPB Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - C4BPB Antibody (Center) AP16055c
    C4BPB Antibody (Center) (Cat. #AP16055c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the C4BPB antibody detected the C4BPB protein (arrow).
  • WB - C4BPB Antibody (Center) AP16055c
    Western blot analysis of C4BPB (arrow) using rabbit polyclonal C4BPB Antibody (Center) (Cat. #AP16055c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the C4BPB gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20851
Other Accession NP_001017365.1, NP_001017367.1, NP_000707.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28357 Da
Antigen Region 125-153 aa
Additional Information
Gene ID 725
Other Names C4b-binding protein beta chain, C4BPB
Target/Specificity This C4BPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human C4BPB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsC4BPB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name C4BPB
Function Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Cellular Location Secreted.
Research Areas
Citations (0)

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This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.


Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Buil, A., et al. Blood 115(23):4644-4650(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)

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$ 295.00
$ 99.00
Cat# AP16055c
(40 western blots)
Availability: In Stock
Bulk Size
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