|Application ||WB, E|
|Other Accession||Q6AYS6, Q8BVL3, Q5EA77, NP_055563.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||52901 Da|
|Antigen Region||53-82 aa|
|Other Names||Sorting nexin-17, SNX17, KIAA0064|
|Target/Specificity||This SNX17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human SNX17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNX17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).|
|Cellular Location||Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. [provided by RefSeq].
Lee, J., et al. J. Biol. Chem. 283(17):11501-11508(2008)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Czubayko, M., et al. Biochem. Biophys. Res. Commun. 345(3):1264-1272(2006)
van Kerkhof, P., et al. EMBO J. 24(16):2851-2861(2005)
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