|Application ||WB, E|
|Other Accession||NP_001121681.1, NP_000328.2, NP_758447.1|
|Calculated MW||32071 Da|
|Antigen Region||232-261 aa|
|Other Names||Delta-sarcoglycan, Delta-SG, 35 kDa dystrophin-associated glycoprotein, 35DAG, SGCD|
|Target/Specificity||This SGCD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the C-terminal region of human SGCD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SGCD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|
|Cellular Location||Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton|
|Tissue Location||Most strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Ordonez-Razo, R.M., et al. Genet Test Mol Biomarkers 14(2):237-240(2010)
Lin, W.Y., et al. BMC Res Notes 3, 26 (2010) :
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