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HCRTR1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HCRTR1 Antibody (Center) AP16116c
    HCRTR1 Antibody (Center) (Cat. #AP16116c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the HCRTR1 antibody detected the HCRTR1 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O43613
Other Accession P56718, P58307, Q0GBZ5, NP_001516.2, O97661
Reactivity Human
Predicted Bovine, Mouse, Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47536 Da
Antigen Region 270-298 aa
Additional Information
Gene ID 3061
Other Names Orexin receptor type 1, Ox-1-R, Ox1-R, Ox1R, Hypocretin receptor type 1, HCRTR1
Target/Specificity This HCRTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-298 amino acids from the Central region of human HCRTR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHCRTR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCRTR1
Function Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.

References

Peltonen, H.M., et al. Biochim. Biophys. Acta 1803(10):1206-1212(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Turunen, P.M., et al. Br. J. Pharmacol. 159(1):212-221(2010)
El Firar, A., et al. FASEB J. 23(12):4069-4080(2009)

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$ 295.00
$ 99.00
Cat# AP16116c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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