|Application ||WB, E|
|Other Accession||NP_001107025.1, NP_751893.3|
|Calculated MW||69047 Da|
|Antigen Region||594-622 aa|
|Other Names||Interleukin-1 receptor-associated kinase-like 2, IRAK-2, mu-IRAK-2, Irak2|
|Target/Specificity||This Mouse Irak2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-622 amino acids from the C-terminal region of mouse Irak2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Irak2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|
|Tissue Location||Ubiquitously expressed, with a higher expression observed in brain, spleen and liver. Isoform 1 and isoform 2 are considered agonist and isoform 3 and isoform 4 are considered antagonist|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Irak2 binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization (By similarity).
Hou, J., et al. J. Immunol. 183(3):2150-2158(2009)
Conner, J.R., et al. J. Exp. Med. 206(7):1615-1631(2009)
Wan, Y., et al. J. Biol. Chem. 284(16):10367-10375(2009)
Elzinga, B.M., et al. J. Biol. Chem. 284(3):1394-1409(2009)
Kawagoe, T., et al. Nat. Immunol. 9(6):684-691(2008)
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