|Application ||WB, E|
|Calculated MW||46832 Da|
|Antigen Region||390-418 aa|
|Other Names||STE20-related kinase adapter protein beta, STRAD beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog, ILP-interacting protein homolog, Polyploidy-associated protein kinase, Pseudokinase ALS2CR2, Stradb, Als2cr2, Papk, Syradb|
|Target/Specificity||This Mouse Stradb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of mouse Stradb.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Stradb Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Als2cr2, Papk, Syradb|
|Function||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
Pseudokinase which, in complex with CAB39, binds to and activates STK11. Relocates STK11 from the nucleus to the cytoplasm. Plays an essential role in STK11-mediated G1 cell cycle arrest.
Ling, K.H., et al. Genome Biol. 10 (10), R104 (2009) :
Barnes, A.P., et al. Cell 129(3):549-563(2007)
Nishigaki, K., et al. J. Biol. Chem. 278(15):13520-13530(2003)
Welch, C.L., et al. Mamm. Genome 8(8):620-621(1997)
Welch, C.L., et al. J. Lipid Res. 37(7):1406-1421(1996)
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