|Application ||WB, E|
|Other Accession||Q4KLH5, Q8K2K6, Q2TA45, NP_004495.2, NP_001128661.1, NP_001128660.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||58260 Da|
|Antigen Region||1-30 aa|
|Other Names||Arf-GAP domain and FG repeat-containing protein 1, HIV-1 Rev-binding protein, Nucleoporin-like protein RIP, Rev-interacting protein, Rev/Rex activation domain-binding protein, AGFG1, HRB, RAB, RIP|
|Target/Specificity||This AGFG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human AGFG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AGFG1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HRB, RAB, RIP|
|Function||Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.|
|Cellular Location||Nucleus. Cytoplasmic vesicle.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene.
Bowes, J.D., et al. Pharmacogenet. Genomics 19(4):319-323(2009)
Chaineau, M., et al. J. Biol. Chem. 283(49):34365-34373(2008)
Pryor, P.R., et al. Cell 134(5):817-827(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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