|Application ||WB, E|
|Other Accession||Q8BXQ2, NP_057021.2, NP_001171658.1, NP_001171657.1|
|Calculated MW||65700 Da|
|Antigen Region||392-421 aa|
|Other Names||GPI transamidase component PIG-T, Phosphatidylinositol-glycan biosynthesis class T protein, PIGT|
|Target/Specificity||This PIGT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392-421 amino acids from the C-terminal region of human PIGT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIGT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Several transcript variants encoding different isoforms have been found for this gene.
Li, H.L., et al. FEBS Lett. 580(7):1723-1728(2006)
Vainauskas, S., et al. J. Biol. Chem. 280(16):16402-16409(2005)
Ohishi, K., et al. J. Biol. Chem. 278(16):13959-13967(2003)
Eisenhaber, B., et al. Bioessays 25(4):367-385(2003)
Vainauskas, S., et al. J. Biol. Chem. 277(34):30535-30542(2002)
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