|Application ||WB, E|
|Other Accession||P84096, NP_001656.2|
|Calculated MW||21309 Da|
|Antigen Region||99-128 aa|
|Other Names||Rho-related GTP-binding protein RhoG, RHOG, ARHG|
|Target/Specificity||This RHOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-128 amino acids from the C-terminal region of human RHOG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RHOG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
ARHG is a member of the RAS superfamily of genes, which encode GTP-binding proteins that act in the pathway of signal transduction and play a key role in the regulation of cellular functions.
Hiramoto-Yamaki, N., et al. J. Cell Biol. 190(3):461-477(2010)
Segat, L., et al. Vaccine 28(10):2201-2206(2010)
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :
Roppenser, B., et al. J. Cell. Sci. 122 (PT 5), 696-705 (2009) :
van Buul, J.D., et al. J. Cell Biol. 178(7):1279-1293(2007)
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