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RHOG Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P84095 |
| Other Accession | P84096, NP_001656.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21309 Da |
| Antigen Region | 99-128 aa |
| Gene ID | 391 |
|---|---|
| Other Names | Rho-related GTP-binding protein RhoG, RHOG, ARHG |
| Target/Specificity | This RHOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-128 amino acids from the C-terminal region of human RHOG. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RHOG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RHOG |
|---|---|
| Synonyms | ARHG |
| Function | Plays a role in immunological synaptic F-actin density and architecture organization (PubMed:33513601). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (PubMed:33513601). Required for the formation of membrane ruffles during macropinocytosis (PubMed:15133129). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (PubMed:17875742). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (PubMed:33513601). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (PubMed:33513601). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (PubMed:33513601). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (PubMed:33513601). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ARHG is a member of the RAS superfamily of genes, which encode GTP-binding proteins that act in the pathway of signal transduction and play a key role in the regulation of cellular functions.
References
Hiramoto-Yamaki, N., et al. J. Cell Biol. 190(3):461-477(2010)
Segat, L., et al. Vaccine 28(10):2201-2206(2010)
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :
Roppenser, B., et al. J. Cell. Sci. 122 (PT 5), 696-705 (2009) :
van Buul, J.D., et al. J. Cell Biol. 178(7):1279-1293(2007)
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