|Application ||WB, E|
|Other Accession||NP_005428.1, NP_001138732.1, NP_001138734.1|
|Calculated MW||69726 Da|
|Antigen Region||496-524 aa|
|Other Names||Nuclear receptor coactivator 4, NCoA-4, Androgen receptor coactivator 70 kDa protein, 70 kDa AR-activator, 70 kDa androgen receptor coactivator, Androgen receptor-associated protein of 70 kDa, Ret-activating protein ELE1, NCOA4, ARA70, ELE1, RFG|
|Target/Specificity||This NCOA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 496-524 amino acids from the C-terminal region of human NCOA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NCOA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARA70, ELE1, RFG|
|Function||Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.|
|Tissue Location||Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma.
Sadow, P.M., et al. Endocr. Pathol. 21(2):73-79(2010)
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :
Richardson, D.S., et al. Cancer Res. 69(11):4861-4869(2009)
Peng, Y., et al. Am. J. Pathol. 172(1):225-235(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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