|Application ||WB, E|
|Calculated MW||39222 Da|
|Antigen Region||142-171 aa|
|Other Names||Immunoglobulin-binding protein 1, B-cell signal transduction molecule alpha 4, Protein alpha-4, CD79a-binding protein 1, Protein phosphatase 2/4/6 regulatory subunit, Renal carcinoma antigen NY-REN-16, IGBP1, IBP1|
|Target/Specificity||This IGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-171 amino acids from the Central region of human IGBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IGBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.|
|Tissue Location||Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.
McDonald, W.J., et al. J. Cell. Biochem. 110(5):1123-1129(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Fielhaber, J.A., et al. J. Biol. Chem. 284(36):24341-24353(2009)
Chen, G.I., et al. J. Biol. Chem. 283(43):29273-29284(2008)
Aranda-Orgilles, B., et al. PLoS ONE 3 (10), E3507 (2008) :
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