|Application ||WB, IF, E|
|Other Accession||Q01713, P79288, O35739, NP_001197.1|
|Calculated MW||27235 Da|
|Antigen Region||29-57 aa|
|Other Names||Krueppel-like factor 9, Basic transcription element-binding protein 1, BTE-binding protein 1, GC-box-binding protein 1, Transcription factor BTEB1, KLF9, BTEB, BTEB1|
|Target/Specificity||This KLF9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human KLF9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLF9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).|
|Tissue Location||Epidermis (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription.
Du, H., et al. Biol. Reprod. 83(2):205-211(2010)
Pabona, J.M., et al. Endocrinology 151(7):3396-3406(2010)
Gamper, I., et al. Exp. Hematol. 37(5):539-548(2009)
Kang, L., et al. Pathol. Int. 58(6):334-338(2008)
Simmen, F.A., et al. Reprod. Biol. Endocrinol. 6, 41 (2008) :
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