|Application ||WB, E|
|Other Accession||NP_001128626.1, NP_001128625.1|
|Calculated MW||54212 Da|
|Antigen Region||29-58 aa|
|Other Names||Zinc transporter ZIP14, LIV-1 subfamily of ZIP zinc transporter 4, LZT-Hs4, Solute carrier family 39 member 14, Zrt- and Irt-like protein 14, ZIP-14, SLC39A14, KIAA0062, ZIP14|
|Target/Specificity||This SLC39A14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human SLC39A14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC39A14 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, lamellipodium Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae|
|Tissue Location||Expressed in liver and in brain by large neurons in the globus pallidus, the insular cortex and the dentate nucleus and to a lower extent in the putamen and the caudate nucleus (at protein level) (PubMed:27231142). Isoform 1 is ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes (PubMed:15642354, PubMed:7584044, PubMed:27231142). Isoform 3 is widely expressed but not detected in brain, heart, skeletal muscle and fetal skin (PubMed:27231142)|
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Provided below are standard protocols that you may find useful for product applications.
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Gao, J., et al. J. Biol. Chem. 283(31):21462-21468(2008)
Liuzzi, J.P., et al. Proc. Natl. Acad. Sci. U.S.A. 102(19):6843-6848(2005)
Taylor, K.M., et al. FEBS Lett. 579(2):427-432(2005)
Taylor, K.M., et al. Biochim. Biophys. Acta 1611 (1-2), 16-30 (2003) :
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