|Application ||WB, E|
|Other Accession||A0JNC0, NP_001159588.1, NP_003266.1|
|Calculated MW||40569 Da|
|Antigen Region||170-198 aa|
|Other Names||Tropomodulin-1, Erythrocyte tropomodulin, E-Tmod, TMOD1, D9S57E, TMOD|
|Target/Specificity||This TMOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-198 amino acids from the Central region of human TMOD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMOD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.|
|Cellular Location||Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).|
|Tissue Location||Highly expressed in the erythrocyte, heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
TMOD1 is a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene.
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Kong, K.Y., et al. J. Biol. Chem. 281(14):9589-9599(2006)
Vera, C., et al. Arch. Biochem. Biophys. 444(2):130-138(2005)
Pawlak, G., et al. Int. J. Cancer 110(3):368-373(2004)
Rho, S.B., et al. FEBS Lett. 557 (1-3), 57-63 (2004) :
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