|Application ||WB, E|
|Calculated MW||122329 Da|
|Antigen Region||1-30 aa|
|Other Names||Myelin transcription factor 1, MyT1, Myelin transcription factor I, MyTI, PLPB1, Proteolipid protein-binding protein, MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1|
|Target/Specificity||This MYT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MYT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0835, KIAA1050, MTF1, MYTI, PLPB1|
|Function||Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up- regulation of myelin gene transcription.|
|Tissue Location||Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.|
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Provided below are standard protocols that you may find useful for product applications.
MYT1 is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.
Choi, H.S., et al. Mol. Cell. Biol. 29(8):2168-2180(2009)
Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)
Vana, A.C., et al. Glia 55(7):687-697(2007)
Nielsen, J.A., et al. Mol. Cell. Neurosci. 25(1):111-123(2004)
Nakajima, H., et al. J. Biol. Chem. 278(28):25277-25280(2003)
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