|Application ||WB, E|
|Other Accession||Q7ZXR3, P61600, Q2PFM2, Q58ED9, NP_852669.1, NP_852668.1, NP_057184.1|
|Predicted||Zebrafish, Monkey, Mouse, Xenopus|
|Calculated MW||20368 Da|
|Antigen Region||127-155 aa|
|Other Names||N-alpha-acetyltransferase 20, Methionine N-acetyltransferase, N-acetyltransferase 5, N-terminal acetyltransferase B complex catalytic subunit NAA20, N-terminal acetyltransferase B complex catalytic subunit NAT5, NatB complex subunit NAT5, NatB catalytic subunit, NAA20, NAT5|
|Target/Specificity||This NAT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the C-terminal region of human NAT5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NAT5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM].
Kuo, H.P., et al. Sci Signal 3 (108), RA9 (2010) :
Evjenth, R., et al. J. Biol. Chem. 284(45):31122-31129(2009)
Polevoda, B., et al. BMC Proc 3 SUPPL 6, S2 (2009) :
Starheim, K.K., et al. Biochem. J. 415(2):325-331(2008)
Sanchez-Puig, N., et al. Protein Sci. 15(8):1968-1976(2006)
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