|Application ||WB, E|
|Calculated MW||18999 Da|
|Antigen Region||98-126 aa|
|Other Names||Translocon-associated protein subunit delta, TRAP-delta, Signal sequence receptor subunit delta, SSR-delta, SSR4, TRAPD|
|Target/Specificity||This SSR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the Central region of human SSR4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SSR4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them, and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric to the ALD gene. Although alternative splicing of exon 5 has not been detected in human SSR4, transcript variants missing the region homologous to human exon 5 have been detected in both Xenopus laevis and Mus musculus.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Wang, Z., et al. Melanoma Res. 14(2):107-114(2004)
Miyazaki, K., et al. J. Biol. Chem. 279(12):11327-11335(2004)
Wang, L., et al. FEBS Lett. 457(3):316-322(1999)
Dodson, G., et al. Curr. Opin. Struct. Biol. 8(2):189-194(1998)
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