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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KLHL25 Antibody (N-term)   

KLHL25 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KLHL25 Antibody (N-term) AP16430a
    KLHL25 Antibody (N-term) (Cat. #AP16430a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the KLHL25 antibody detected the KLHL25 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H0H3
Other Accession Q4KLM4, Q8R2P1, NP_071925.2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 65923 Da
Antigen Region 62-91 aa
Additional Information
Gene ID 64410
Other Names Kelch-like protein 25, Ectoderm-neural cortex protein 2, ENC-2, KLHL25, ENC2
Target/Specificity This KLHL25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the N-terminal region of human KLHL25.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLHL25 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL25
Synonyms ENC2
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Research Areas
Citations (0)

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Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007) :
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

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$ 295.00
$ 99.00
Cat# AP16430a
(40 western blots)
Availability: In Stock
Bulk Size
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