|Application ||WB, E|
|Calculated MW||50183 Da|
|Antigen Region||2-31 aa|
|Other Names||Tapasin-related protein, TAPASIN-R, TAP-binding protein-like, TAP-binding protein-related protein, TAPBP-R, Tapasin-like, TAPBPL|
|Target/Specificity||This TAPBPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human TAPBPL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAPBPL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single-pass type I membrane protein Microsome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573)|
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Provided below are standard protocols that you may find useful for product applications.
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM].
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
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Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Teng, M.S., et al. Eur. J. Immunol. 32(4):1059-1068(2002)
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