|Application ||WB, E|
|Calculated MW||71718 Da|
|Antigen Region||231-259 aa|
|Other Names||Centrosomal protein of 72 kDa, Cep72, CEP72, KIAA1519|
|Target/Specificity||This CEP72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids from the Central region of human CEP72.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CEP72 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner|
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Provided below are standard protocols that you may find useful for product applications.
CEP72 is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
Briggs, F.B., et al. Genes Immun. 11(3):199-208(2010)
Oshimori, N., et al. EMBO J. 28(14):2066-2076(2009)
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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