|Application ||WB, E|
|Calculated MW||44795 Da|
|Antigen Region||293-321 aa|
|Other Names||G-protein coupled receptor family C group 5 member B, A-69G121, Retinoic acid-induced gene 2 protein, RAIG-2, GPRC5B, RAIG2|
|Target/Specificity||This GPRC5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human GPRC5B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPRC5B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein Note=Localized in the plasma membrane and perinuclear vesicles|
|Tissue Location||Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.|
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Provided below are standard protocols that you may find useful for product applications.
GPRC5B is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Robbins, M.J., et al. Genomics 67(1):8-18(2000)
Brauner-Osborne, H., et al. Genomics 65(2):121-128(2000)
Loftus, B.J., et al. Genomics 60(3):295-308(1999)
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