CXXC1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9P0U4 |
Other Accession | Q9CWW7, NP_055408.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 75712 Da |
Antigen Region | 326-354 aa |
Gene ID | 30827 |
---|---|
Other Names | CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1, CXXC1, CFP1, CGBP, PCCX1, PHF18 |
Target/Specificity | This CXXC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the Central region of human CXXC1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CXXC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CXXC1 |
---|---|
Synonyms | CFP1, CGBP, PCCX1, PHF18 |
Function | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. |
Cellular Location | Nucleus speckle. Nucleus {ECO:0000250|UniProtKB:Q9CWW7} Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).
References
Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)
Tate, C.M., et al. Mol. Cell. Biol. 29(14):3817-3831(2009)
Butler, J.S., et al. DNA Cell Biol. 27(10):533-543(2008)
Ansari, K.I., et al. Biochim. Biophys. Acta 1779(1):66-73(2008)
Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)
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