|Application ||WB, E|
|Other Accession||Q9CWW7, NP_055408.2|
|Calculated MW||75712 Da|
|Antigen Region||326-354 aa|
|Other Names||CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1, CXXC1, CFP1, CGBP, PCCX1, PHF18|
|Target/Specificity||This CXXC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the Central region of human CXXC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CXXC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CFP1, CGBP, PCCX1, PHF18|
|Function||Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.|
|Cellular Location||Nucleus speckle Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).
Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)
Tate, C.M., et al. Mol. Cell. Biol. 29(14):3817-3831(2009)
Butler, J.S., et al. DNA Cell Biol. 27(10):533-543(2008)
Ansari, K.I., et al. Biochim. Biophys. Acta 1779(1):66-73(2008)
Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)
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