|Application ||WB, E|
|Other Accession||Q9CWW7, NP_055408.2|
|Calculated MW||75712 Da|
|Antigen Region||326-354 aa|
|Other Names||CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1, CXXC1, CFP1, CGBP, PCCX1, PHF18|
|Target/Specificity||This CXXC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the Central region of human CXXC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CXXC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CFP1, CGBP, PCCX1, PHF18|
|Function||Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.|
|Cellular Location||Nucleus speckle Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes|
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Provided below are standard protocols that you may find useful for product applications.
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).
Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)
Tate, C.M., et al. Mol. Cell. Biol. 29(14):3817-3831(2009)
Butler, J.S., et al. DNA Cell Biol. 27(10):533-543(2008)
Ansari, K.I., et al. Biochim. Biophys. Acta 1779(1):66-73(2008)
Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)
If you have any additional inquiries please email technical services at email@example.com.