|Application ||WB, E|
|Other Accession||O35738, NP_009180.3|
|Calculated MW||44240 Da|
|Antigen Region||283-312 aa|
|Other Names||Krueppel-like factor 12, Transcriptional repressor AP-2rep, KLF12, AP2REP|
|Target/Specificity||This KLF12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-312 amino acids from the C-terminal region of human KLF12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLF12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.|
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Provided below are standard protocols that you may find useful for product applications.
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Eyre, S., et al. Ann. Rheum. Dis. 69(7):1407-1408(2010)
Wieczorek, S., et al. J. Mol. Med. 88(4):413-421(2010)
Petersen, G.M., et al. Nat. Genet. 42(3):224-228(2010)
Nakamura, Y., et al. Int. J. Cancer 125(8):1859-1867(2009)
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