|Application ||WB, IF, E|
|Calculated MW||35193 Da|
|Antigen Region||220-248 aa|
|Other Names||Fos-related antigen 2, FRA-2, FOSL2, FRA2|
|Target/Specificity||This FOSL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-248 amino acids from the C-terminal region of human FOSL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FOSL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Bozec, A., et al. J. Cell Biol. 190(6):1093-1106(2010)
Bolat, I., et al. Folia Histochem. Cytobiol. 48(2):197-201(2010)
Reich, N., et al. Arthritis Rheum. 62(1):280-290(2010)
Maurer, B., et al. Circulation 120(23):2367-2376(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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