|Application ||WB, IF, E|
|Calculated MW||35193 Da|
|Antigen Region||220-248 aa|
|Other Names||Fos-related antigen 2, FRA-2, FOSL2, FRA2|
|Target/Specificity||This FOSL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-248 amino acids from the C-terminal region of human FOSL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FOSL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.|
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Provided below are standard protocols that you may find useful for product applications.
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Bozec, A., et al. J. Cell Biol. 190(6):1093-1106(2010)
Bolat, I., et al. Folia Histochem. Cytobiol. 48(2):197-201(2010)
Reich, N., et al. Arthritis Rheum. 62(1):280-290(2010)
Maurer, B., et al. Circulation 120(23):2367-2376(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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