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PHF21A Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PHF21A Antibody (Center) AP16505c
    PHF21A Antibody (Center) (Cat. #AP16505c) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the PHF21A antibody detected the PHF21A protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96BD5
Other Accession Q6ZPK0, NP_057705.3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 74854 Da
Antigen Region 436-464 aa
Additional Information
Gene ID 51317
Other Names PHD finger protein 21A, BHC80a, BRAF35-HDAC complex protein BHC80, PHF21A, BHC80, KIAA1696
Target/Specificity This PHF21A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 436-464 amino acids from the Central region of human PHF21A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPHF21A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHF21A
Synonyms BHC80, KIAA1696
Function Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Cellular Location Nucleus.
Tissue Location Highly expressed in brain. Expressed at much lower level in other tissues.
Research Areas
Citations (0)

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The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Klajn, A., et al. J. Neurosci. 29(19):6296-6307(2009)
Hailesellasse Sene, K., et al. BMC Genomics 8, 85 (2007) :
Shi, Y.J., et al. Mol. Cell 19(6):857-864(2005)
Iwase, S., et al. Biochem. Biophys. Res. Commun. 322(2):601-608(2004)

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Cat# AP16505c
(40 western blots)
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