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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GLIS2 Antibody (Center)   

GLIS2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GLIS2 Antibody (Center) AP16510c
    GLIS2 Antibody (Center) (Cat. #AP16510c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the GLIS2 antibody detected the GLIS2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BZE0
Other Accession NP_115964.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 55689 Da
Antigen Region 173-202 aa
Additional Information
Gene ID 84662
Other Names Zinc finger protein GLIS2, GLI-similar 2, Neuronal Krueppel-like protein, GLIS2, NKL
Target/Specificity This GLIS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human GLIS2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGLIS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLIS2
Synonyms NKL
Function Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).
Cellular Location Nucleus speckle. Cytoplasm
Tissue Location Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon
Research Areas
Citations (0)

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This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.


Attanasio, M., et al. Nat. Genet. 39(8):1018-1024(2007)
Hosking, C.R., et al. Mol. Biol. Cell 18(5):1918-1927(2007)
Kim, Y.S., et al. FEBS Lett. 581(5):858-864(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Kim, Y.S., et al. Nucleic Acids Res. 31(19):5513-5525(2003)

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$ 295.00
$ 99.00
Cat# AP16510c
(40 western blots)
Availability: In Stock
Bulk Size
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